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Episode 005 – Chekhov’s Uterus

In which we review Season 3, Episode 7 Community of Dreadful Fear and Hate and use Chekhov’s Gun as a somewhat strained device to link Donnie’s menstrual flow monitoring, Cosima’s relapse, Shay’s (possibly triggering) smoothies, and why you don’t want to check your urine for misfolded proteins.

Next episode: Misfolded Proteins and Prions, Oh My.

Links:

Learn more about histology and epithelium at:

http://www.histology-world.com/contents/contents.htm#epithelium 

More advanced information at:

http://medcell.med.yale.edu/histology/epithelia_lab.php

Excellent overview of endometriosis:

http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0072685/

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Show Notes

This episode is brought to you by Mercury Retrograde. Drive one today!
In which we miss Paul, wonder aloud about clones and dominant handedness, and begin a longer conversation (to be picked up in the next non-episode episode) about proteins, prions and disease.

Alchemical symbols (as seen in The Island of Dr. Moreau and the Blue Period paintings of Rachel Duncan):

http://alchemicaldiagrams.blogspot.com/2011/10/alchemy-symbols-with-meanings.html

Genes and Handedness

http://www.geneticliteracyproject.org/2014/12/02/left-handedness-genes-and-a-matter-of-chance/

HOMEWORK!

If you’re interested in boning up before Episode 6 – Misfolded Proteins and Prions, Oh My! here is an article to start reading. It’s a good overview with introductory material.

Protein Misfolding and Neurodegenerative Diseases
http://www.nature.com/scitable/topicpage/protein-misfolding-and-degenerative-diseases-14434929

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We figured out where Dr. Ethan Duncan got his symbols from for his secret genetic sequence code: alchemy.

Here are the alchemical symbols that he used, with their traditional meanings. You can see them in the copy of The Island of Dr. Moreau that he gave Kira, and in Rachel’s watercolors.

Alchemical Symbols with Meanings

These are the diagrams and figures used to calculate the flight of the pencil from the fire extinguisher in Season 2 Episode 10 of Orphan Black, and covered in Episode 3 of the podcast. It turns out that you can use the Projectile Motion Simulator and skip all this, but then you’d miss the amusing force diagrams.

Episode 3 Diagram 1

Numbers for Calculations:

Pencil: 7″ = about 17 cm, weight = 8 grams = 128 grains, diameter = 1 cm, height = 1 cm.

Eye: 2.4 cm height, 2.1 cm length, 78% water (for density)

Brain: 14cm width, 16.7 cm length, 9.3 cm height

Fire Extinguisher: 195 PSI = 1344 kPa

Rachel Duncan = 5’7″ (with heels), distance from top of head to center of eyeball approximately 5″.

Distance between fire extinguisher to Rachel approximately 7 feet.

Angle of fire from fire extinguisher to Rachel’s eye: 14.5 degrees.

Episode 3 Diagram 2

Episode 3 Diagram 3

Show Notes: Episode 003 – They Saved Rachel’s Brain?

Physics

Force Diagrams with Measurements used can be found at http://www.youwonscience.com/shownotes_ep003/

Projectile Motion Equations:
http://www.physicsclassroom.com/class/vectors/Lesson-2/Horizontally-Launched-Projectiles-Problem-Solving

Projectile Motion Simulation (with bonus Buick and Michelangelo statue)
https://phet.colorado.edu/en/simulation/projectile-motion

Inelastic Collision Calculator:
http://hyperphysics.phy-astr.gsu.edu/hbase/inecol2.html

Transorbital Intracranial Injuries:

Transorbital penetrating Brain Injury images
http://radiopaedia.org/cases/transorbital-penetrating-brain-injury
S Matsumoto, K Hasuo, A Mizushima, F Mihara, M Fukui, T Shirouzu, and K Masuda
Intracranial penetrating injuries via the optic canal.
Am J Neuroradiol 1998 19: 1163-5
http://www.ajnr.org/content/19/6/1163.long
Daniel M. Bursick, Robert G. Selker.
Intracranial pencil injuries.
Surgical Neurology, Volume 16, Issue 6, December 1981
http://dx.doi.org/10.1016/0090-3019(81)90235-4.
(NOTE:Article is paywalled: boo.)
http://www.sciencedirect.com/science/article/pii/0090301981902354
Frontal Lobe: Functions and Injuries

http://en.wikipedia.org/wiki/Frontal_lobe
The Centre for Neuro Skills | Brain Injury | Frontal Lobes
http://www.neuroskills.com/brain-injury/frontal-lobes.php

Neuropsychology (For samples of graded naming tests)
http://www.slideshare.net/monipoli/neuropsychology-compiled-report
Phineas Gage

http://en.wikipedia.org/wiki/Phineas_Gage

Phineas Gage: Neuroscience’s Most Famous Patient
http://www.smithsonianmag.com/history/phineas-gage-neurosciences-most-famous-patient-11390067/?no-ist

Isaac Newton Sticking Things in His Eye

http://www.lib.cam.ac.uk/exhibitions/Footprints_of_the_Lion/8Bodkin.html (from his notebook)

http://thegruesomeblog.com/2014/07/27/isaac-newton-his-eye-and-his-bodkin/ (if you want to see a bodkin)

http://www.baumanrarebooks.com/blog/the-story-behind-opticks-by-sir-isaac-newton/

Show Notes: Episode 1 Leda and the Swan(Man)

Bullfinch’s Mythology: Full Text:
http://www.sacred-texts.com/cla/bulf/

Theseus-Daedelus-Castor and Pollux:
http://www.sacred-texts.com/cla/bulf/bulf19.htm

The Trojan War:
http://www.sacred-texts.com/cla/bulf/bulf26.htm

Classical Source Material on Leda, Queen of Sparta
http://www.theoi.com/Heroine/Leda.html

Wikipedia:
Leda and the Swan: http://en.wikipedia.org/wiki/Leda_and_the_Swan

Castor and Pollux: http://en.wikipedia.org/wiki/Castor_and_Pollux
Size of the Human Genome:

http://www.ncbi.nlm.nih.gov/books/NBK21134/#A5276

Short Tandem Repeats and Familial Relationships:
http://www.cstl.nist.gov/strbase/pub_pres/OConnor_USCIS_interpretation%20of%20DNA.pdf
(PDF of a PowerPoint presentation explaining how one assesses familial relationships via STR testing)

Also, http://en.wikipedia.org/wiki/DNA_profiling#STR_analysis

Thank you for listening!

 

We wrote an article about Orphan Black for Dame Magazine.

Will The Castor Clones Ruin Orphan Black?

(Hint: We don’t think so.)

 

Show Notes:

Bullfinch’s Mythology: Full Text:
http://www.sacred-texts.com/cla/bulf/

Theseus-Daedelus-Castor and Pollux:
http://www.sacred-texts.com/cla/bulf/bulf19.htm

The Trojan War:
http://www.sacred-texts.com/cla/bulf/bulf26.htm

Classical Source Material on Leda, Queen of Sparta
http://www.theoi.com/Heroine/Leda.html

Wikipedia:
Leda and the Swan: http://en.wikipedia.org/wiki/Leda_and_the_Swan

Castor and Pollux: http://en.wikipedia.org/wiki/Castor_and_Pollux
Size of the Human Genome:

http://www.ncbi.nlm.nih.gov/books/NBK21134/#A5276

Short Tandem Repeats and Familial Relationships:
http://www.cstl.nist.gov/strbase/pub_pres/OConnor_USCIS_interpretation%20of%20DNA.pdf (PDF of a PowerPoint presentation explaining how one assesses familial relationships via STR testing)

Also, http://en.wikipedia.org/wiki/DNA_profiling#STR_analysis
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