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Monthly Archives: June 2015

In which we wonder about why John Sadler had to die, discuss how hard it was to watch S03E09, and then explain mosaicism, chimerism and why mothers always have their children close to their internal organs.

Also: Shout outs to Tatiana is Everyone and Science Vs. Hollywood.

Enjoy the finale!


CSI Chimera Episode and Blaschko’s Lines:



Chimeras, Mosaics and Other Fun Stuff:



Blood Group Chimerism In Human Multiple Births Is Not Rare: (PDF File)

“Pregnancy may thus establish a long-term, low-grade chimeric state in the human female.”

Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.


Y-chromosome DNA Is Present in the Blood of Female Dogs Suggesting the Presence of Fetal Microchimerism: (open access)

Tatiana is Everyone: An Orphan Black Podcast

Science Vs Hollywood




Facebook: You Won Science: An Orphan Black Podcast


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As mentioned in Episode 7 of the podcast, we’re taking your guesses as to where Orphan Black will take Season 4’s episode titles from. Please leave your vote in the comments:

A) The Island of Dr. Moreau, H.G. Wells

B) Brave New World, Aldous Huxley

C) Other (Please give the title and author!)

We’ll collect answers here and at our Facebook Page until Saturday 27 June and then announce the winner. If nothing else, we’ll get some good suggestions for books to read while waiting for the next season.

Thank you as always.

In which we briefly consider why Cosima hates to be the patient and whether the next faction hails from Cambridge, MA, then give you a crash course in proteins, prions and biochemistry. There will not be a test, but there are some handouts if you want them:

Conspiracy Maps: Leda Clones & Castor Clones


Proteins and Prions: UCSF Medical Center


Prions: On The Trail of Killer Proteins


Wikipedia: Prion


Stanley Pruisner’s Nobel Lecture on Prions


Also, if you have a suggestion for the source of next season’s episode titles, let us know. The poll will be available on our website and Facebook Page on Monday June 15th.

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Facebook: You Won Science: An Orphan Black Podcast

Twitter: @You_Won_Science

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These are the diagrams referred to in Episode 7, “Misfolded Proteins and Prions, Oh My!”


Map Of Castor Clone Players


Map of Leda Clone Players (will probably be outdated as on June 15 2015, because new episode.)

Episode 005 – Chekhov’s Uterus

In which we review Season 3, Episode 7 Community of Dreadful Fear and Hate and use Chekhov’s Gun as a somewhat strained device to link Donnie’s menstrual flow monitoring, Cosima’s relapse, Shay’s (possibly triggering) smoothies, and why you don’t want to check your urine for misfolded proteins.

Next episode: Misfolded Proteins and Prions, Oh My.


Learn more about histology and epithelium at: 

More advanced information at:

Excellent overview of endometriosis:


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Show Notes

This episode is brought to you by Mercury Retrograde. Drive one today!
In which we miss Paul, wonder aloud about clones and dominant handedness, and begin a longer conversation (to be picked up in the next non-episode episode) about proteins, prions and disease.

Alchemical symbols (as seen in The Island of Dr. Moreau and the Blue Period paintings of Rachel Duncan):

Genes and Handedness


If you’re interested in boning up before Episode 6 – Misfolded Proteins and Prions, Oh My! here is an article to start reading. It’s a good overview with introductory material.

Protein Misfolding and Neurodegenerative Diseases


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